For a list of the other versions, see Cobra Commander.
In G.I. Joe: Renegades, Cobra Commander (voiced by Charlie Adler) is reinterpreted as a corporate businessman known as Adam DeCobray, head of the legitimate Cobra pharmaceutical corporation which masks his terrorist organization. His appearance is similar to his live-action incarnations, save for some details: His lower face is damaged and covered in a plastic shielding wrap. His skin is paler than average humans, and has a red/blue eye and a bald head. He is egotistic, but nowhere as pompous in his promotional speech making as some of his other incarnations nor as personally arrogant. Cobra Commander keeps his disfigured appearance a secret from the world, only ever appearing to the public as a normal-looking virtual simulation over video screens except to the Joes and Baroness, who knew his true self.
In the episode "The Enemy of My Enemy," Cobra Commander receives a giant cobra from Doctor Mindbender that he calls Serpentor. During Destro's negotiations with Adam DeCobray, Destro's plot to have Doctor Mindbender captured by G.I. Joe is found out causing Cobra Commander to show his true form to Destro. He ends up unleashing Serpentor on Destro, takes control of M.A.R.S. Industries, and places a metal mask on Destro that only Cobra Commander can remove.
In the episode "Homecoming" Pt. 1, the Joes learn of Adam DeCobray's true form when they stole a console at a Cobra Industries Christmas Party. Cobra Commander had to resort to capturing Duke's parents only for them to be rescued by Duke. In the episode "Homecoming" Pt. 2, Cobra Commander sends Baroness to steal back the console on the same military train that Flint is escorting the apprehended G.I. Joe members on.
In the episode "Prodigal", Cobra Commander has come down with an unknown illness and is forced to wear a facemask in order for him to breathe properly. He becomes beyond enraged when Patient X was taken by the Joes, as he uses him to create the perfect human/Bio-Viper hybrid as a step towards immortality. Mindbender, however, sees this as an opportunity for Cobra to test out the control chip he implanted in Patient X's head. After tracking down Patient X and the Joes, Cobra Commander mentally orders him to revert into a Bio-Viper and kill the Joes. After Ripcord manages to fight control of the chip and rejoins the Joes, Cobra Commander was less than pleased at Mindbender's failure and sics Serpentor on him. Mindbender convinces Commander that he needs him in order to stay alive, though Cobra Commander blast him against the wall and warns him that Patient X must be retrieved alive if the both of them are to remain alive.