Destro is Cobra's weapons developer. Several iterations of the character have appeared in different series:
- Destro (RAH) - the independent weapons supplier who is one of the most complex characters in the A Real American Hero series.
- Destro (Sigma 6) - Cobra Commander's right-hand man in the Sigma 6 series.
- Destro (Resolute) - A weapons supplier commonly allied with the Baroness in the Resolute series.
- Destro (Movie) - One of the main villains of the 2009 film.
- Destro (Renegades) in GI Joe Renegades